华西虚拟期刊

华西虚拟期刊

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Here, the authors present a thermo-responsive shape memory polymer (SMP) foam that can be programmed to control the preosteoblast behavior by changing porous architecture during cell cultivation. The preosteoblast cells are seeded on the SMP foams with temporarily compressed pore structure. Results show that cells preferentially align along the pore length direction. After the pore recovery at 37 degrees C, cells remain attached and viable but change their topography in a tangential direction along the pore edge. This work indicates the shape-memory actuated porous structure in SMP foam can control the cell behavior. This may provide an effective method for studying cell responses to dynamic environment and facilitate the healthy and optimal development of tissue engineering.

Key words: MESENCHYMAL STEM-CELLS; COMPOSITE SCAFFOLDS; IN-VIVO; BONE; ALIGNMENT; ORIENTATION; MUSCLE; MATRIX; REGENERATION; ARCHITECTURE

引用本文: . . 华西虚拟期刊, 2000, 1(1): -. doi: 10.1002/adem.201600343 复制

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