华西虚拟期刊

华西虚拟期刊

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Oral infectious diseases may lead to bone loss, which makes it difficult to achieve satisfactory restoration. The rise of multidrug resistant bacteria has put forward severe challenges to the use of antibiotics. Silver (Ag) has long been known as a strong antibacterial agent In clinic, gelatin sponge with colloid silver is used to reduce tooth extraction complication. To investigate how this material affect infected bone defects, methicillin-resistant Staphylococcus aureus (MRSA) infected 3-mm-diameter cranial defects were created in adult female Sprague-Dawley rats. One week after infection, the defects were debrided of all nonviable tissue and then implanted with gelatin sponge with colloid silver (gelatin/Ag group) or gelatin alone (gelatin group). At 2 and 3 days after debridement, significantly lower mRNA expression levels of IL-6 and TNF-alpha and lower plate colony count value were detected in gelatin/Ag group than control. Micro-CT analysis showed a significant increase of newly formed bone volume fraction (BV/TV) in gelatin/Ag treated defects. The HE stained cranium sections also showed a faster rate of defect closure in gelatin/Ag group than control. These findings demonstrated that gelatin sponge with colloid silver can effectively reduce the infection caused by MRSA in cranial defects and accelerate bone healing process. (C) 2016 Published by Elsevier B.V.

Key words: ANTIMICROBIAL ACTIVITY; PSEUDOMONAS-AERUGINOSA; DRUG-DELIVERY; IN-VITRO; NANOPARTICLES; ANTIBACTERIAL; COMPOSITE; SCAFFOLDS; HYDROGEL; COATINGS

引用本文: . . 华西虚拟期刊, 2000, 1(1): 371-377-. doi: 10.1016/j.msec.2016.09.015 复制

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