Through advances in analytical methods to detect glycoproteins and to determine glycan structures, there have been increasing reports of protein glycosylation in bacteria. In this review, we summarize the known pathways for bacterial protein glycosylation: lipid carrier-mediated 'en bloc' glycosylation; and cytoplasmic stepwise protein glycosylation. The exploitation of bacterial protein glycosylation systems, especially the 'mix and match' of three independent but similar pathways (oligosaccharyltransferase-mediated protein glycosylation, lipopolysaccharide and peptidoglycan biosynthesis) in Gram-negative bacteria for glycoengineering recombinant glycoproteins is also discussed.
Key words: ENTEROTOXIGENIC ESCHERICHIA-COLI; O-LINKED GLYCOSYLATION; CAMPYLOBACTER-JEJUNI; FUNCTIONAL-CHARACTERIZATION; FLAGELLAR GLYCOSYLATION; HELICOBACTER-PYLORI; PSEUDAMINIC ACID; PSEUDOMONAS-AERUGINOSA-1244 PILIN; MYCOBACTERIUM-TUBERCULOSIS; BURKHOLDERIA-THAILANDENSIS
引用本文： . . 华西虚拟期刊, 2000, 1(1): 59-72-. doi: 10.2217/fmb-2016-0166 复制