中华眼底病杂志

中华眼底病杂志

超广角眼底自身荧光在眼底疾病中的应用研究现状及进展

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超广角眼底自身荧光(FAF)是一项新兴的非侵入性检查技术,成像范围约200°,能发现既往FAF不能发现的周边部视网膜病变,更加全面客观地反映视网膜色素上皮(RPE)细胞内脂褐质的含量与分布情况,评价RPE细胞的代谢状态。超广角FAF可发现老年性黄斑变性(AMD)患眼周边部视网膜普遍存在异常自身荧光表现,且不同自身荧光表现可能对其亚型的诊断和治疗有影响;有利于监测中心性浆液性脉络膜视网膜病变患眼的视网膜下液,且能准确反应无视网膜下液患眼的外层视网膜变化;有助于确定葡萄膜炎的类型,并可全面显示疾病演变过程;可更好地评估视网膜营养不良及视网膜色素变性患眼外周光感受器细胞层及RPE信息,全面评估其视网膜功能和监测疾病进展情况;可辅助评价孔源性视网膜脱离患眼巩膜扣带手术后近期疗效及RPE细胞功能。超广角FAF未来有可能改变眼底疾病认知干预水平现状,推动眼底疾病临床及科研水平的提高。

Ultra-wide field fundus autofluorescence (FAF) imaging is a new noninvasive technique with an imaging range of about 200 °. It can detect peripheral retinal lesions that cannot be found in previous FAFs and more objectively reflect intracellular content and distribution of lipofuscin in the retinal pigment epithelium (RPE) and RPE cell metabolic status. The ultra-wide field FAF can find the abnormal autofluorescence (AF) in the peripheral retina of the eyes of age-related macular degeneration (AMD), and different AF manifestations may have an impact on the diagnosis and treatment of the different AMD subtypes. It is helpful to evaluate subretinal fluid in the eyes of central serous choroidal retinopathy and can accurately detect the changes in the outer retina of the eyes without subretinal fluid. It can help to determine the type of uveitis and fully display the evolution of the disease. It can also assess the peripheral photoreceptor cell layer and RPE in patients with retinal dystrophy and retinitis pigmentosa, and comprehensively evaluate their retinal function and monitor the progress of disease. It can also assist in the evaluation of the short-term efficacy and RPE cell function after the scleral buckling surgery for patients with rhegmatogenous retinal detachment. In the future, ultra-wide field FAF may change the knowledge and intervention strategy of ocular fundus diseases and promote the clinical and scientific research in this field.

关键词: 视网膜疾病/诊断; 脉络膜疾病/诊断; 黄斑变性/诊断; 诊断技术,眼科; 荧光; 综述

Key words: Retinal diseases/diagnosis; Choroid diseases/diagnosis; Macular degeneration/diagnosis; Diagnostic techniques, ophthalmological; Fluorescence; Review

引用本文: 许阿敏, 陈长征. 超广角眼底自身荧光在眼底疾病中的应用研究现状及进展. 中华眼底病杂志, 2018, 34(1): 89-92. doi: 10.3760/cma.j.issn.1005-1015.2018.01.027 复制

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