华西虚拟期刊

华西虚拟期刊

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Breviscapine, extracted from the herb Erigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 mg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment. Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of interleukin-6.

Key words: CENTRAL-NERVOUS-SYSTEM; TRANSGENIC MICE; CEREBROSPINAL-FLUID; MESSENGER-RNA; RATS; INHIBITION; OVEREXPRESSION; ASTROCYTES; MECHANISM; CYTOKINE

引用本文: . . 华西虚拟期刊, 2000, 1(1): 90-95-. doi: 10.4103/1673-5374.198990 复制

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