Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy

中国的基因与细胞治疗:21世纪的飞跃发展和重要贡献

各位新年好! 

国际知名的基因治疗杂志Human Gene Therapy《人类基因治疗》春节期间发表了中国专刊,刘德培院士和魏于全院士受邀作为客座主编,该专辑发表了18篇中国科学家写的评论, 综述和原创研究文章,内容涉及基因与细胞治疗药物监管、病毒与非病毒载体、基因编辑、基因修饰的干细胞治疗等技术,以及基因治疗与细胞治疗在肿瘤、心血管疾病、遗传性疾病等方面的应用进展、反映了中国科学家在该领域取得的最新进展,论文目录详见该文最后,阅读全文见http://online.liebertpub.com/toc/hum/29/2。 


Human Gene Therapy的主编Terence R. Flotte教授与美国基因与细胞治疗学会主席,Guangping Gao教授 (高光坪教授),用中英文同时发表了编者按 “Gene and Cell Therapy in China: Highlighting Excellence in the 21st Century” (中国的基因与细胞治疗:21世纪的飞跃发展和重要贡献)。他们指出:值此中国农历新年之际, 我们很荣幸能在《人类基因治疗》杂志上发表本期由刘德培教授和魏于全教授这两位中国基因和细胞治疗领域的领军人物客串主编的中国特刊。在本特刊中, 我们不仅收集了一系列的评论, 综述和原创研究文章, 同时, 我们还力求重点介绍这个世界上人口最多而科学和技术正在以前所未有的速度飞跃发展的国家在基因和细胞治疗转化研究领域里所取得的成就和重要贡献……..”。




封面由川大华西医院生物治疗国家重点实验室的李昕欣博士与王玮副教授设计,其设计的灵感来源于女娲补天这个典故。相传在中国远古时代,四根擎天大柱倾倒,天空出现巨大的洞口,九州大地裂毁,一时间生灵涂炭。此时女娲冶炼五色石,以修补苍天,将有缺陷的天空修补完整,自此中原大地上恢复了平静,世间万物皆依照秩序运转。而基因治疗的原理则是将外源正常基因导入靶细胞,以纠正或补偿因基因缺陷和异常引起的疾病,以达到治疗目的,与女娲补天的典故想契合。更重要的是,女娲补天展现了人类改造天地的雄伟气魄和与自然斗争的大无畏精神,基因治疗的探索亦是体现人类与自然不懈抗争的精神,二者在精神层面互通,采用此典故表现基因治疗的概念可以说浑然天成。


Special Issue: Chinese Gene and Cell Therapy Research

Guest Editors: Yuquan Wei, MD, PhD, and De-Pei Liu, MD, PhD


Gene and Cell Therapy in China: Highlighting Excellence in the 21st Century 中国的基因与细胞治疗: 21世纪的飞跃发展和重要贡献

Terence R. Flotte, Guangping Gao (高光坪)

Human Gene Therapy. Feb 2018, 29(2): 97-97.

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Special Commentaries and Review Articles

Applications of Virus Vector–Mediated Gene Therapy in China  

Qiong Lin, Deng-Gao Wang, Zhu-Qin Zhang, De-Pei Liu

Human Gene Therapy. Feb 2018, 29(2): 98-109.

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Current Status of Nonviral Vectors for Gene Therapy in China  

Li Liu, Jingyun Yang, Ke Men, Zhiyao He, Min Luo, Zhiyong Qian, Xiawei Wei, Yuquan Wei

Human Gene Therapy. Feb 2018, 29(2): 110-120.

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Considerations for Clinical Review of Cellular Therapy Products: Perspectives of the China Food and Drug Administration Center for Drug Evaluation  

Yantong Liu, Chenyang Zhao, Liucun Gao, Huan Yang, Ruyi He, Chenyan Gao

Human Gene Therapy. Feb 2018, 29(2): 121-127.

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National Rare Diseases Registry System of China and Related Cohort Studies: Vision and Roadmap  

Shi Feng, Shuang Liu, Chong Zhu, Mengchun Gong, Yicheng Zhu, Shuyang Zhang

Human Gene Therapy. Feb 2018, 29(2): 128-135.

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Recent Advances in Therapeutic Genome Editing in China

Yang Yang, Qingnan Wang, Qian Li, Ke Men, Zhiyao He, Hongxin Deng, Weizhi Ji, Yuquan Wei

Human Gene Therapy. Feb 2018, 29(2): 136-145.

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Gene Therapy for Hemophilia and Duchenne Muscular Dystrophy in China

Xionghao Liu, Mujun Liu, Lingqian Wu, Desheng Liang

Human Gene Therapy. Feb 2018, 29(2): 146-150.

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Fighting Cancer with Viruses: Oncolytic Virus Therapy in China

Ding Wei, Jing Xu, Xin-Yuan Liu, Zhi-Nan Chen, Huijie Bian

Human Gene Therapy. Feb 2018, 29(2): 151-159.

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The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

Wei-Wei Zhang, Longjiang Li, Dinggang Li, Jiliang Liu, Xiuqin Li, Wei Li, Xiaolong Xu, Michael J. Zhang, Lois A. Chandler, Hong Lin, Aiguo Hu, Wei Xu, Dominic Man-Kit Lam

Human Gene Therapy. Feb 2018, 29(2): 160-179.

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Development of Gene Therapeutics for Head and Neck Cancer in China: From Bench to Bedside

Wei Guo, Hao Song

Human Gene Therapy. Feb 2018, 29(2): 180-187.

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Stem-Cell Therapy Advances in China

Lei Hu, Bin Zhao, Songlin Wang

Human Gene Therapy. Feb 2018, 29(2): 188-196.

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Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World

Jingzhi Zhang, Jingbin Yan, Fanyi Zeng

Human Gene Therapy. Feb 2018, 29(2): 197-203.

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Oncolytic Viruses for Tumor Precision Imaging and Radiotherapy

Zi J. Wu, Feng R. Tang, Zhao-Wu Ma, Xiao-Chun Peng, Ying Xiang, Yanling Zhang, Jingbo Kang, Jiafu Ji, Xiao Q. Liu, Xian-Wang Wang, Hong-Wu Xin, Bo X. Ren

Human Gene Therapy. Feb 2018, 29(2): 204-222.

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Research Articles

In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9

Zhi-Yao He, Ya-Guang Zhang, Yu-Han Yang, Cui-Cui Ma, Ping Wang, Wei Du, Ling Li, Rong Xiang, Xiang-Rong Song, Xia Zhao, Shao-Hua Yao, Yu-Quan Wei

Human Gene Therapy. Feb 2018, 29(2): 223-233.

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Interleukin-35 Gene-Modified Mesenchymal Stem Cells Protect Concanavalin A–Induced Fulminant Hepatitis by Decreasing the Interferon Gamma Level

Wei Wang, Hao Guo, Hongyue Li, Yongjia Yan, Chao Wu, Xiaodong Wang, Xianghui He, Na Zhao

Human Gene Therapy. Feb 2018, 29(2): 234-241.

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Treatment of Uterine Sarcoma with rAd-p53 (Gendicine) Followed by Chemotherapy: Clinical Study of TP53 Gene Therapy

Yu Xia, Zhenhua Du, Xinyan Wang, Xiuqin Li

Human Gene Therapy. Feb 2018, 29(2): 242-250.

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Double-Dose Adenovirus-Mediated Adjuvant Gene Therapy Improves Liver Transplantation Outcomes in Patients with Advanced Hepatocellular Carcinoma

Ruidong Zhu, Danhui Weng, Shichun Lu, Dongdong Lin, Menglong Wang, Dongdong Chen, Jun Lv, Hongjun Li, Fudong Lv, Ling Xi, Jianfeng Zhou, Ding Ma, Ning Li

Human Gene Therapy. Feb 2018, 29(2): 251-258.

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MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation

Yan Zhang, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Dijie Li, Jianhua Ma, Xiaoli Ma, Peihong Su, Wuxia Qiu, Chaofei Yang, Pai Wang, Siyu Li, Ge Zhang, Liping Wang, Airong Qian, Cory J. Xian

Human Gene Therapy. Feb 2018, 29(2): 259-270.

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Transplantation of Hepatocyte Growth Factor–Modified Dental Pulp Stem Cells Prevents Bone Loss in the Early Phase of Ovariectomy-Induced Osteoporosis  

Fanxuan Kong, Xuefeng Shi, Fengjun Xiao, Yuefeng Yang, Xiaoyan Zhang, Li-Sheng Wang, Chu-Tse Wu, Hua Wang

Human Gene Therapy. Feb 2018, 29(2): 271-282.

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Signal Transduction and Targeted Therapy简介

《Signal Transduction and Targeted Therapy》(STTT)是自然出版集团和四川大学华西医院生物治疗国家重点实验室合作出版的全英文生物医学专业期刊(网站:http://www.nature. com/sigtrans,点击本网站最下方"阅读原文”)。主编由美国俄亥俄州立大学Carlo M. Croce教授(美国三院院士,Cancer Research前主编),UCSD的张康教授、川大华西医院魏于全教授/院士担任。有来自全球等多个国家及地区的多位相关领域的近百位著名学者组成编委会。本杂志每周五发表文章,欢迎各位投稿,包括论著或综述。对于原创性成果采取“快速通道”模式,帮助作者以最快的速度发表文章,最快一周可接收。该杂志发表论文可免收发表费。该杂志投稿格式不限,正式发表之前再按杂志格式修改。感谢将此信息转发给您们的同事、朋友以及学生等。



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